Cure MPS1 Project
Cure MPS1 Project
Jude McCaleb is a joyful 9-year-old from Tennessee who loves sports, farming, and collecting sports cards. Diagnosed with MPS1 attenuated at almost eight years old, Jude has overcome countless obstacles with faith, strength, and determination. His story is one of raising awareness, inspiring hope, and spreading joy through his favorite anthem, “Raise a Hallelujah.”
Jude’s family stands by him through every challenge. His mom shares, “Our prayer was answered with his diagnosis, but it also became a new starting line. We rely on faith to guide us every step of the way.”
Jude was diagnosed with MPS1 attenuated in December 2022 after years of joint stiffness, pain, and unanswered questions. His family had spent years navigating countless tests and doctor visits, only to feel overlooked at times. “It was the most painful relief to finally get a diagnosis,” his mom explains.
MPS1 is a rare genetic disorder that prevents Jude’s body from breaking down certain molecules, causing toxic buildup in his organs and tissues. This condition requires lifelong medical intervention and monitoring.
Jude began enzyme replacement therapy (ERT) on Rare Disease Day—an unplanned but symbolic moment that highlights how his journey is intertwined with hope and awareness.
ERT involves weekly 5-6 hour infusions, helping Jude’s body manage symptoms of MPS1. Despite these treatments, Jude’s joyful spirit never fades. From advocating at community events to leading by example with his faith, he inspires all who meet him. His family emphasizes, “This journey is about glorifying God through every trial and triumph.”
2015: Jude is born and becomes the first grandchild on both sides of his family
2020: Joint pain and stiffness worsen; diagnostic tests begin
2022: Diagnosis of MPS1 attenuated is confirmed
2023: Jude begins weekly ERT on Rare Disease Day
Faith and Community Connection
When Jude gathers with other children affected by MPS1, it’s like reuniting with family. “They don’t need to explain their struggles—they just understand,” his mom explains. These rare disease gatherings provide a crucial sense of belonging and hope.
The McCaleb family works to advocate for others facing similar challenges, sharing Jude’s story to spread awareness and raise support for research into a cure.
Jude and his younger brother Jesse share an unbreakable bond. “Jesse is Jude’s protector, full of fire and energy,” their mom says. Though they have typical sibling fights, Jesse never lets Jude fight alone. “God knew Jude would need Jesse to be his constant strength,” she adds.
Together, they face every challenge with love and resilience, inspiring those around them with their brotherhood and courage
The Cure MPS1 Project
The Kennedy Ladd Foundation is committed to finding a cure for MPS1. By supporting the Cure MPS1 Project, you help fund vital research, treatment innovations, and support for families navigating this rare disease.
Where Your Donation Goes:
Research to find a cure and better treatment options for MPS1
Therapy and support for children with MPS1
Hope for affected families
In this heartfelt episode, Jude’s mom reflects on the power of faith, community, and resilience. She shares how Jude’s favorite song, “Raise a Hallelujah,” became a beacon of light in their darkest moments.
How You Can Help
Jude’s journey is one of courage, hope, and love. You can support children like Jude in the following ways:
Donate: Every dollar moves us closer to a cure and better treatment options for MPS1.
Share: Raise awareness by sharing Jude’s story.
Pray: Join us in praying for strength and healing.
